Kaye C I, Nadler H L
J Lab Clin Med. 1975 Sep;86(3):422-9.
Cystine glutathione transhydrogenase, cystine-reductase, and glutathion reductase activities were studied in cultivated skin fibroblasts of control subjects and of three patients with cystinosis. Specific activity, pH optima, electrophoretic mobility, and kinetic parameters were described. Evidence for two isoenzyme forms of cystine-glutathione transhydrogenase was obtained. No difference was detected in activity of biochemical characteristics of these enzymes between cells of cystinotic and normal subjects.
在对照受试者和三名胱氨酸病患者的培养皮肤成纤维细胞中研究了胱氨酸谷胱甘肽转氢酶、胱氨酸还原酶和谷胱甘肽还原酶的活性。描述了比活性、最适pH值、电泳迁移率和动力学参数。获得了胱氨酸-谷胱甘肽转氢酶两种同工酶形式的证据。胱氨酸病患者和正常受试者细胞之间这些酶的生化特性活性未检测到差异。
