Zhao Shangping, Yang Mingshi
Critical Medicine Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jul;38(7):754-60. doi: 10.3969/j.issn.1672-7347.2013.07.017.
Sepsis is the systemic inflammatory response to infection and a major cause of mortality in critical patients. The severe disorder of immune system is the common pathophysiological changes in septic patients. Mesenchymal stem cells (MSCs) have shown great immunoloregulation properties in recent studies. It can increase the level of IL-10, an anti-inflammatory cytokine, promote the secretion of prostaglandin E2 (PGE2), indolamine 2,3-dioxygenase (IDO), and regulate the proliferation, differentiation and function of the immune cells such as mononuclear macrophage, t-lymphocytes, natural killer cells and so on. MSCs may provide new ideas for the treatment of sepsis.
脓毒症是机体对感染的全身性炎症反应，是危重症患者死亡的主要原因。免疫系统的严重紊乱是脓毒症患者常见的病理生理变化。间充质干细胞（MSCs）在最近的研究中显示出强大的免疫调节特性。它可以提高抗炎细胞因子白细胞介素-10的水平，促进前列腺素E2（PGE2）、吲哚胺2,3-双加氧酶（IDO）的分泌，并调节单核巨噬细胞、T淋巴细胞、自然杀伤细胞等免疫细胞的增殖、分化和功能。间充质干细胞可能为脓毒症的治疗提供新思路。
