Br J Psychiatry. 2013 Aug;203(2):84-5. doi: 10.1192/bjp.bp.113.127191.
Despite rigorous research into the genetics of neuropsychiatric disorders, the mechanism by which polygenic risk leads to complex clinical phenotypes remains unclear. The Encyclopedia of DNA Elements (ENCODE) project gives us new insight into gene regulation, and gene-gene and gene-environment interaction. Better understanding of these key genomic mechanisms may provide the answers we have been searching for.
尽管对神经精神疾病的遗传学进行了严格的研究，但多基因风险导致复杂临床表型的机制仍不清楚。DNA 元件百科全书 (ENCODE) 项目为我们提供了对基因调控以及基因-基因和基因-环境相互作用的新见解。更好地理解这些关键的基因组机制可能为我们一直在寻找的答案提供依据。
