Children's Hospital Los Angeles.
Blood. 2013 Aug 1;122(5):623-4. doi: 10.1182/blood-2013-06-507376.
In this issue of Blood, Dertschnig and colleagues1 demonstrate in mice that acute graft-versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–expressing medullary thymic epithelial cells (Aire1 mTEC) and a decrease in the diversity of Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection. Both of these abnormalities are reversed by the peritransplant administration of the epithelial protectant drug, fibroblast growth factor 7(Fgf7).
在本期《Blood》中，Dertschnig 及其同事 1 在小鼠中证明，急性移植物抗宿主病 (GHVD) 导致表达自身免疫受体的骨髓胸腺上皮细胞 (Aire1 mTEC) 明显减少，以及对有效阴性胸腺选择所必需的、依赖 Aire 的组织特异性外周自身抗原 (TRAs) 的多样性减少。这两种异常都可以通过移植前给予上皮保护药物成纤维细胞生长因子 7（Fgf7）来逆转。
