Department of Pathology, Haartman Institute, University of Helsinki and HUSLAB, , Helsinki, Finland.
J Clin Pathol. 2013 Dec;66(12):1076-80. doi: 10.1136/jclinpath-2013-201513. Epub 2013 Aug 1.
Characterisation of adrenal tumours is an important clinical problem. Unenhanced CT is the primary imaging modality to assess the nature of these lesions.
To study the correlation between unenhanced CT attenuation value and the specific histopathology, as well as the proportion of lipid-poor eosinophilic cells in adrenocortical tumours.
We studied retrospectively primary adrenocortical tumours that had been operated on at Helsinki University Central Hospital between 2002 and 2008. Of 171 tumours, 79 had appropriate preoperative CT scans and were included in the study. We evaluated the unenhanced CT attenuation values (Hounsfield units, HU) of these tumours and determined their histopathological diagnosis by the Weiss scoring system. We also assessed the proportion of lipid-poor eosinophilic cells for each tumour.
Unenhanced CT attenuation value (HU) in adrenocortical tumours correlated well with the proportion of lipid-poor eosinophilic cells (rs=0.750, p<0.001). HU and Weiss score also had a correlation (rs=0.582, p<0.001).
Unenhanced CT attenuation value correlates well with the percentage of lipid-poor eosinophilic cells, but unenhanced CT attenuation value fails to differentiate between benign lipid-poor adenomas and malignant adrenocortical tumours. All adrenocortical tumours with unenhanced CT attenuation value ≤10 HU are histologically benign lipid-rich tumours.
肾上腺肿瘤的特征是一个重要的临床问题。未增强 CT 是评估这些病变性质的主要成像方式。
研究未增强 CT 衰减值与特定组织病理学以及肾上腺皮质肿瘤中贫脂嗜酸细胞比例之间的相关性。
我们回顾性研究了 2002 年至 2008 年在赫尔辛基大学中心医院接受手术的原发性肾上腺皮质肿瘤。在 171 个肿瘤中，有 79 个有合适的术前 CT 扫描，并纳入了研究。我们评估了这些肿瘤的未增强 CT 衰减值（Hounsfield 单位，HU），并通过 Weiss 评分系统确定其组织病理学诊断。我们还评估了每个肿瘤中贫脂嗜酸细胞的比例。
肾上腺皮质肿瘤的未增强 CT 衰减值（HU）与贫脂嗜酸细胞的比例相关性良好（rs=0.750，p<0.001）。HU 和 Weiss 评分也存在相关性（rs=0.582，p<0.001）。
未增强 CT 衰减值与贫脂嗜酸细胞的百分比相关性良好，但未增强 CT 衰减值不能区分良性贫脂腺瘤和恶性肾上腺皮质肿瘤。所有未增强 CT 衰减值≤10 HU 的肾上腺皮质肿瘤均为组织学良性富脂肿瘤。
