Department of Dermatology, University of California Davis, Sacramento, California 95816, USA.
J Rheumatol. 2013 Aug;40(8):1434-7. doi: 10.3899/jrheum.130457.
At the 2012 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Stockholm, Sweden, several GRAPPA members led a panel discussion on cardiovascular (CV) comorbidities of psoriasis and psoriatic arthritis (PsA). The panelists discussed the role of insulin resistance in the pathophysiology of psoriasis, the possible effect of tumor necrosis factor inhibitors on CV comorbidities, and the effect of 12/23 monoclonal antibodies on CV outcomes. The panelists also addressed how lessons from CV comorbidity research could be applied to other areas of comorbidity research in psoriasis and PsA and identified future research directions in this area.
在瑞典斯德哥尔摩举行的 2012 年银屑病和银屑病关节炎研究与评估团体(GRAPPA)年会上,几位 GRAPPA 成员就银屑病和银屑病关节炎(PsA)的心血管(CV)合并症进行了小组讨论。小组成员讨论了胰岛素抵抗在银屑病发病机制中的作用、肿瘤坏死因子抑制剂对 CV 合并症的可能影响,以及 12/23 单克隆抗体对 CV 结果的影响。小组成员还讨论了如何将 CV 合并症研究的经验教训应用于银屑病和 PsA 中其他合并症研究领域,并确定了这一领域的未来研究方向。