Cutolo M, Cimmino M A, Accardo S
Istituto Scientifico di Medicina Interna, Universita' di Genova, Italy.
Clin Rheumatol. 1990 Jun;9(2):242-5. doi: 10.1007/BF02031977.
Two cases of nail involvement associated with primary interphalangeal osteoarthritis of the hand, including leukonychia and longitudinal nail ridge, are reported. Osteoarthritic changes of the distal interphalangeal joints may cause nail lesions by exerting direct pressure on the nail matrix or by interfering with local blood flow. Moreover, inflammation of the Heberden's nodes is often present and seems to participate in the development of nail alteration. In our patients, leukonychia disappeared after local steroidal anti-inflammatory treatment of the osteoarthritic node and longitudinal nail ridge disappeared after treatment with nonsteroidal anti-inflammatory agents.
报告了2例与手部原发性指间骨关节炎相关的指甲受累病例，包括白甲症和指甲纵嵴。远端指间关节的骨关节炎改变可能通过对甲母质施加直接压力或干扰局部血流而导致指甲病变。此外，赫伯登结节的炎症常常存在，似乎参与了指甲改变的发生。在我们的患者中，骨关节炎结节经局部甾体类抗炎治疗后白甲症消失，非甾体类抗炎药治疗后指甲纵嵴消失。
