Storck J, Kirsten R
Institute for Clinical Pharmacology, J. W. Goethe University of Frankfurt, Federal Republic of Germany.
Curr Med Res Opin. 1990;12(2):86-92. doi: 10.1185/03007999009110475.
The effect of urapidil, an a1-antagonist with additional antihypertensive action via central 5HT1A agonism, was determined on platelet aggregation induced by 5HT and adrenaline. The 5HT uptake in human platelets was determined as well. Urapidil inhibited both the 5HT and adrenaline-induced human platelet aggregation and the 5HT uptake by platelets in vitro. The 5HT-induced aggregation was inhibited with a K1 value of 8.8 microM, the adrenaline-induced aggregation with a K1 value of 21.6 microM, and the 5HT uptake non-competitively with a K11 = 11.5 microM and a K12 = 13 microM.
乌拉地尔是一种α1拮抗剂，通过激动中枢5-羟色胺1A（5HT1A）产生额外的降压作用，本研究测定了其对5-羟色胺（5HT）和肾上腺素诱导的血小板聚集的影响。同时也测定了人血小板对5HT的摄取。乌拉地尔在体外可抑制5HT和肾上腺素诱导的人血小板聚集以及血小板对5HT的摄取。5HT诱导的聚集被抑制，K1值为8.8微摩尔；肾上腺素诱导的聚集被抑制，K1值为21.6微摩尔；5HT摄取被非竞争性抑制，K11 = 11.5微摩尔，K12 = 13微摩尔。
