[Clinical significance of urine estriol-125I-radioimmunoassay in obstetric monitoring].

This paper reported the determination of urine E3 in 326 normal pregnancies from 28 to 41 gestational weeks, and 80 abnormal pregnancies by E3-125I-RIA. The results showed that E3 levels in normal pregnancies increased with advance of gestational weeks with their peaks at the 38th week and decreased gradually after the 40th week. There was a positive correlation between urine E3 and the 12 hour urine E/C ratio (r = 0.798, P less than 0.001). In monitoring the high-risk pregnancies, we found 92.3% with E3 less than or equal to 10 mg/L in severe PIH, 23.5% in mild and moderate PIH, 37.9% in post-term pregnancy and 78.9% in intrauterine growth retardation (IUGR). It indicated that measurement of urine E3 using E3 125I-RIA is a better index for detecting and screening placenta 1 function.