Scheinman Melvin M
University of California San Francisco, CA, USA.
Rambam Maimonides Med J. 2012 Jul 31;3(3):e0019. doi: 10.5041/RMMJ.10083. Print 2012 Jul.
While Drs Wolff, Parkinson, and White fully described the syndrome in 1930, prior case reports had described the essentials. Over the ensuing century this syndrome has captivated the interest of anatomists, clinical cardiologists, and cardiac surgeons. Stanley Kent described lateral muscular connections over the atrioventricular (AV) groove which he felt were the normal AV connections. The normal AV connections were, however, clearly described by His and Tawara. True right-sided AV connections were initially described by Wood et al., while Öhnell first described left free wall pathways. David Scherf is thought to be the first to describe our current understanding of the pathogenesis of the WPW syndrome in terms of a re-entrant circuit involving both the AV node-His axis as well as the accessory pathway. This hypothesis was not universally accepted, and many theories were applied to explain the clinical findings. The basics of our understanding were established by the brilliant work of Pick, Langendorf, and Katz who by using careful deductive analysis of ECGs were able to define the basic pathophysiological processes. Subsequently, Wellens and Durrer applied invasive electrical stimulation to the heart in order to confirm the pathophysiological processes. Sealy and his colleagues at Duke University Medical Center were the first to successfully surgically divide an accessory pathway and ushered in the modern era of therapy for these patients. Morady and Scheinman were the first to successfully ablate an accessory pathway (posteroseptal) using high-energy direct-current shocks. Subsequently Jackman, Kuck, Morady, and a number of groups proved the remarkable safety and efficiency of catheter ablation for pathways in all locations using radiofrequency energy. More recently, Gollob et al. first described the gene responsible for a familial form of WPW. The current ability to cure patients with WPW is due to the splendid contributions of individuals from diverse disciplines throughout the world.
虽然沃尔夫医生、帕金森医生和怀特医生在1930年全面描述了该综合征，但此前的病例报告已阐述了其要点。在随后的一个世纪里，这种综合征吸引了解剖学家、临床心脏病学家和心脏外科医生的关注。斯坦利·肯特描述了房室沟上方的外侧肌肉连接，他认为这些是正常的房室连接。然而，希斯和塔瓦拉明确描述了正常的房室连接。真正的右侧房室连接最初由伍德等人描述，而厄内尔首次描述了左侧游离壁通路。大卫·舍尔夫被认为是第一个从涉及房室结 - 希氏束轴以及附加通路的折返环路角度描述我们目前对预激综合征发病机制理解的人。这一假说并未被普遍接受，许多理论被用来解释临床发现。我们理解的基础是由皮克、朗根多夫和卡茨的杰出工作奠定的，他们通过对心电图进行仔细的演绎分析，能够确定基本的病理生理过程。随后，韦伦斯和杜勒对心脏进行侵入性电刺激以证实病理生理过程。杜克大学医学中心的西利及其同事是第一个成功通过手术切断附加通路的，开创了这些患者治疗的现代时代。莫拉迪和申曼是第一个使用高能直流电电击成功消融附加通路（后间隔）的人。随后，杰克曼、库克、莫拉迪和其他一些团队证明了使用射频能量对所有部位的通路进行导管消融具有显著的安全性和有效性。最近，戈洛布等人首次描述了导致家族性预激综合征的基因。目前治愈预激综合征患者的能力得益于世界各地不同学科人员的卓越贡献。
