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先天性心脏缺陷手术的新技术。

New technologies for surgery of the congenital cardiac defect.

作者信息

Kalfa David, Bacha Emile

机构信息

Pediatric Cardiac Surgery, Columbia University, Morgan Stanley Children's Hospital of New York-Presbyterian, New York, USA.

出版信息

Rambam Maimonides Med J. 2013 Jul 25;4(3):e0019. doi: 10.5041/RMMJ.10119. Print 2013 Jul.

Abstract

The surgical repair of complex congenital heart defects frequently requires additional tissue in various forms, such as patches, conduits, and valves. These devices often require replacement over a patient's lifetime because of degeneration, calcification, or lack of growth. The main new technologies in congenital cardiac surgery aim at, on the one hand, avoiding such reoperations and, on the other hand, improving long-term outcomes of devices used to repair or replace diseased structural malformations. These technologies are: 1) new patches: CorMatrix® patches made of decellularized porcine small intestinal submucosa extracellular matrix; 2) new devices: the Melody® valve (for percutaneous pulmonary valve implantation) and tissue-engineered valved conduits (either decellularized scaffolds or polymeric scaffolds); and 3) new emerging fields, such as antenatal corrective cardiac surgery or robotically assisted congenital cardiac surgical procedures. These new technologies for structural malformation surgery are still in their infancy but certainly present great promise for the future. But the translation of these emerging technologies to routine health care and public health policy will also largely depend on economic considerations, value judgments, and political factors.

摘要

复杂先天性心脏缺陷的外科修复常常需要各种形式的额外组织,如补片、管道和瓣膜。由于退化、钙化或生长不足,这些装置通常需要在患者的一生中进行更换。先天性心脏外科的主要新技术一方面旨在避免此类再次手术,另一方面旨在改善用于修复或替换患病结构畸形的装置的长期效果。这些技术包括:1)新型补片:由脱细胞猪小肠黏膜下层细胞外基质制成的CorMatrix®补片;2)新型装置:Melody®瓣膜(用于经皮肺动脉瓣植入)和组织工程带瓣管道(脱细胞支架或聚合物支架);3)新兴领域,如产前心脏矫正手术或机器人辅助先天性心脏手术。这些用于结构畸形手术的新技术仍处于起步阶段,但未来肯定前景广阔。但这些新兴技术向常规医疗保健和公共卫生政策的转化在很大程度上也将取决于经济因素、价值判断和政治因素。

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