Demir Caner Feyzi, Ozdemir Hasan Hüseyin, Müngen Bülent
Department of Neurology, Firat (Euphrates) University, Elazig, Turkey.
Acta Medica (Hradec Kralove). 2013;56(1):36-8. doi: 10.14712/18059694.2014.37.
The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora's disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy.
本文描述了两例与拉福拉病和翁韦里希特-伦德伯格型进行性肌阵挛癫痫（PME）无关的病例，这两例患者接受了托吡酯（TPM）作为肌阵挛附加治疗。在开始托吡酯治疗后，两例患者的肌阵挛发作频率均显著降低，生活质量得到改善。托吡酯似乎是PME病例中一种有用的替代药物，可考虑用于辅助治疗。
