Balázs M
Department of Pathology, János Hospital, Budapest, Hungary.
Dis Colon Rectum. 1990 Sep;33(9):773-7. doi: 10.1007/BF02052325.
Five cases of giant inflammatory polyps associated with idiopathic inflammatory bowel disease are reported. Polyps produced intestinal obstruction in three cases; consequently, surgery was performed. In a further two cases, intestinal bleeding was improved by endoscopic polypectomy. Electron microscopy showed fibroblasts, myofibroblasts, mast cells, lymphocytes, collagen fibers, capillaries, and venules. Remnants of the original mucosal epithelial cells, smooth muscle cells, and hypertrophic autonomous nerve plexuses were noted. Nerve fibers were interwoven with the matrix of the polyps. Mast cells were closely linked with vessels, nerves, and collagen fibers. They may have an important role in the excessive granulation, angiogenesis, and fibrotic process in giant inflammatory polyps.
报告了5例与特发性炎症性肠病相关的巨大炎性息肉病例。息肉在3例中导致肠梗阻；因此，进行了手术。另外2例中，内镜下息肉切除术改善了肠道出血。电子显微镜检查显示有成纤维细胞、肌成纤维细胞、肥大细胞、淋巴细胞、胶原纤维、毛细血管和小静脉。观察到原始黏膜上皮细胞、平滑肌细胞和肥厚的自主神经丛的残余。神经纤维与息肉基质交织在一起。肥大细胞与血管、神经和胶原纤维紧密相连。它们可能在巨大炎性息肉的过度肉芽组织形成、血管生成和纤维化过程中起重要作用。
