Mongan A M, Malik V, Rowley S, Claxton Z, Muldoon C, O'Toole D, Ravi N, Reynolds J V
Department of Surgery, St James's Hospital, James's St, Dublin 8.
Ir Med J. 2013 Jun;106(6):176-9.
Gastrointestinal stromal tumour (GIST) is the most common mesenchymal tumour of the gastrointestinal tract. The aim of this study was to present the experience of a single centre. A prospective GIST database from 1997 to 2011 in a tertiary referral centre wa reviewed. 78 patients (36 male/42 female) with a median age of 66 (range 10-93) were diagnosed with GIST during this period. Surgery was the primary treatment for 70 patients (90%); 19 (24%) resections were laparoscopic. Nineteen patients (24%) received Imatinib therapy. At a median follow up of 3 years, 10 patients (15%) had recurrence. Five-year survival was 89%. Surgery remains the mainstay of treatment. Minimally invasive approaches may be carried out with high cure rates. This study highlights the changing presentation and treatment approach, as well as the excellent outcomes achievable for GIST tumours.
胃肠道间质瘤（GIST）是胃肠道最常见的间叶组织肿瘤。本研究旨在介绍单中心的经验。回顾了一家三级转诊中心1997年至2011年的前瞻性GIST数据库。在此期间，78例患者（36例男性/42例女性）被诊断为GIST，中位年龄为66岁（范围10 - 93岁）。手术是70例患者（90%）的主要治疗方式；19例（24%）切除为腹腔镜手术。19例患者（24%）接受了伊马替尼治疗。中位随访3年时，10例患者（15%）出现复发。5年生存率为89%。手术仍然是主要的治疗方法。微创方法可以实现高治愈率。本研究突出了GIST肿瘤不断变化的临床表现和治疗方法，以及可实现的良好治疗效果。
