Mak Vivien, Ip Dennis, Mang Oscar, Dalal Chinmay, Huang Steven, Gerrie Alina, Gillan Tanya, Ramadan Khaled M, Toze Cynthia, Au Wing-Yan
Department of Medicine and Geriatrics, Princess Margaret Hospital , Hong Kong.
Leuk Lymphoma. 2014 Apr;55(4):824-7. doi: 10.3109/10428194.2013.827785. Epub 2013 Sep 12.
The incidence of chronic lymphocytic leukemia (CLL) in the Asian population is up to 10 times lower than that in Caucasians. Studies on CLL in Asian residents in North America may help to determine the relative genetic and environmental causes of such a difference. Computerized records of CLL incidence from the combined British Columbia (BC) databases (n = 2736) and the Hong Kong Cancer Registry (HKCR, n = 572) were traced. Ethnic Chinese cases of CLL in BC were identified (n = 35). The world age standardized rates (WASRs) of CLL (per 100 000) were calculated in BC (1.71), HK (0.28) and BC Chinese (0.4), respectively. Using standard incidence ratios (SIRs), the observed BC Chinese case number was comparable to the figure projected from HK rates (SIR 1.3, p = 0.1) but significantly lower than the figure following BC rates (SIR 0.22, p < 0.0001). The difference was maintained over both genders, in all age groups and through the years. Our data over three decades suggest that genetic factors outplay environmental factors to give lower CLL rates in Chinese.
亚洲人群中慢性淋巴细胞白血病（CLL）的发病率比白种人低达10倍。对北美亚裔居民的CLL研究可能有助于确定造成这种差异的相对遗传和环境因素。追溯了来自不列颠哥伦比亚省（BC）综合数据库（n = 2736）和香港癌症登记处（HKCR，n = 572）的CLL发病率计算机记录。确定了BC省的华裔CLL病例（n = 35）。分别计算了BC省（1.71）、香港（0.28）和BC省华裔（0.4）的CLL世界年龄标准化发病率（每10万人）。使用标准化发病率（SIR），观察到的BC省华裔病例数与根据香港发病率预测的数字相当（SIR 1.3，p = 0.1），但显著低于按照BC省发病率预测的数字（SIR 0.22，p < 0.0001）。这种差异在所有性别、所有年龄组以及多年来都持续存在。我们三十年的数据表明，遗传因素比环境因素对中国人较低的CLL发病率影响更大。
