Division of Hematology and Leukemia/BMT Program of BC, University of British Columbia, Vancouver, BC, Canada.
Leuk Lymphoma. 2011 Dec;52(12):2316-20. doi: 10.3109/10428194.2011.601475. Epub 2011 Aug 18.
The etiology of plasma cell myeloma (PCM) is largely unknown. Its incidence varies widely in different ethnic groups. Migrant study may help determine the relative contributions of genetic versus environmental factors to PCM pathogenesis. We performed a retrospective review of the computerized records of all patients diagnosed with PCM between 1975 and 2004 in British Columbia (BC), and identified patients of Chinese ethnicity. This was compared with PCM incidence in Hong Kong (HK) Chinese. Age distributions of HK, BC and BC Chinese populations were obtained from the census departments to calculate world age-standardized rates (WASRs). The WASR of PCM over the 30-year period in BC Chinese was 1.64/100 000 person-years (95% confidence interval [CI] 1.37-1.93). This was similar to the WASR observed in HK (1.78, 95% CI 1.73-1.83), with a standardized incidence ratio (SIR) of 0.91 (95% CI 0.74-1.10). The rate was much lower than that in the BC non-Chinese background population (WASR 3.59, 95% CI 3.50-3.68; SIR 0.46, 95% CI 0.38-0.56). The lower rates in BC Chinese were maintained across all years, both genders and in all age groups above 45 years. Our observations suggest a strong genetic component as the cause of differences in the ethnic predisposition to PCM.
浆细胞骨髓瘤（PCM）的病因在很大程度上尚不清楚。其发病率在不同种族之间差异很大。移民研究可能有助于确定遗传与环境因素对 PCM 发病机制的相对贡献。我们对 1975 年至 2004 年间不列颠哥伦比亚省（BC）所有被诊断为 PCM 的患者的计算机记录进行了回顾性分析，并确定了华裔患者。将其与香港（HK）华裔 PCM 的发病率进行了比较。从人口普查部门获得了 HK、BC 和 BC 华裔人群的年龄分布，以计算世界年龄标准化率（WASR）。BC 华裔人群在 30 年期间的 PCM 的 WASR 为 1.64/100000 人年（95%置信区间 [CI] 1.37-1.93）。这与 HK 观察到的 WASR 相似（1.78，95%CI 1.73-1.83），标准化发病比（SIR）为 0.91（95%CI 0.74-1.10）。这一比率远低于 BC 非华裔背景人群（WASR 3.59，95%CI 3.50-3.68；SIR 0.46，95%CI 0.38-0.56）。BC 华裔人群的低比率在所有年份、所有性别和所有年龄组（45 岁以上）中均保持不变。我们的观察结果表明，遗传因素是导致不同种族对 PCM 易感性差异的主要原因。
