诊断前吸烟与非霍奇金淋巴瘤患者的总生存。
Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma.
机构信息
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Health Studies, University of Chicago, Chicago, IL, USA.
出版信息
Br J Haematol. 2013 Nov;163(3):352-6. doi: 10.1111/bjh.12512. Epub 2013 Aug 2.
Abstract
We examined whether smoking prior to non-Hodgkin lymphoma (NHL) diagnosis was associated with overall survival (OS) and conducted a meta-analysis to assess the evidence relating pre-diagnosis cigarette smoking with OS. Among 523 NHL patients, worse OS was suggested for greater pre-diagnostic smoking habits when compared to never smokers. In the meta-analysis (n = 5 patient populations), inferior OS was observed for greater number of cigarettes smoked per day, years of cigarette smoking, and pack-years of cigarette smoking. The inferior survival was more pronounced for follicular than for diffuse large B cell lymphoma. Pre-diagnosis cigarette smoking may adversely impact the survival of NHL patients.
摘要
我们研究了非霍奇金淋巴瘤（NHL）诊断前吸烟是否与总生存（OS）相关，并进行了荟萃分析以评估与诊断前吸烟与 OS 相关的证据。在 523 名 NHL 患者中，与从不吸烟者相比，有更大的诊断前吸烟习惯提示 OS 更差。在荟萃分析中（n=5 个人群），每天吸烟支数、吸烟年限和吸烟包年数越多，OS 越差。滤泡性比弥漫性大 B 细胞淋巴瘤的生存劣势更为明显。诊断前吸烟可能会对 NHL 患者的生存产生不利影响。
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