Ikpatt N W, Asindi A A, Ekanem I A, Khalil M I
Department of Paediatrics, University of Calabar, Nigeria.
East Afr Med J. 1990 May;67(5):341-7.
Seventy-five cases of childhood cerebral malaria (CM) seen within a 30-month period (January 1986 to June 1988) in the University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria were prospectively studied. Fifty-five percent of the victims were aged 1-5 years while 39% were between 6 and 10 years. Eight percent of the cases were postmortem surprises, their condition having been masked by other complications of malaria. At variance with the accepted definition of CM, 20% of the patients neither convulsed nor lost consciousness. In searching for any delineating premortem features of the disease, a combination of fever, multiple seizures, coma with severe anaemia did appear impressive and also a co-existence of tonic-clonic with pure tonic seizures was highly suspicious. The need to heighten the index of suspicion and encourage extensive research into this lethal aspect of malaria is stressed.
对1986年1月至1988年6月在尼日利亚卡拉巴尔大学教学医院（UCTH）30个月内所见的75例儿童脑型疟疾（CM）进行了前瞻性研究。55%的受害者年龄在1至5岁之间，而39%在6至10岁之间。8%的病例是尸检意外发现，其病情被疟疾的其他并发症所掩盖。与CM的公认定义不同，20%的患者既没有抽搐也没有失去意识。在寻找该疾病任何明确的死前特征时，发热、多次惊厥、伴有严重贫血的昏迷组合确实令人印象深刻，而且强直阵挛性发作与单纯强直性发作并存也高度可疑。强调了提高怀疑指数并鼓励对疟疾这一致命方面进行广泛研究的必要性。
