聚乙二醇-硅烷修饰的金纳米棒在肿瘤组织中保留其光学性质。
PEG-silica-modified gold nanorods that retain their optical properties in tumor tissues.
机构信息
a Department of Applied Chemistry , Faculty of Engineering Kyushu University , 744 Motooka, Nishi-ku, Fukuoka , 819-0395 , Japan .
出版信息
J Biomater Sci Polym Ed. 2013;24(18):2071-80. doi: 10.1080/09205063.2013.823073. Epub 2013 Aug 5.
PMID:23909685
Abstract
Gold nanorods modified with polyethylene glycol (PEG) chains via Au-S bonds form aggregates, and their absorption spectra broaden in tumor tissues. In contrast, the gold nanorods modified here via the crosslinking of PEG chains on the silica shell on gold nanorods showed enhanced permeability and retention effects and retained the optical properties of the original gold nanorods in tumor tissues.
摘要
通过 Au-S 键将聚乙二醇（PEG）链修饰到金纳米棒上会形成聚集体，并且它们的吸收光谱在肿瘤组织中变宽。相比之下，通过交联金纳米棒上的硅壳上的 PEG 链修饰的金纳米棒显示出增强的通透性和保留效应，并在肿瘤组织中保留了原始金纳米棒的光学性质。
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