Edwards Christopher
University Hospital Southampton, Southampton, UK.
J Pain Palliat Care Pharmacother. 2013 Aug;27(3):286-7; discussion 287-8. doi: 10.3109/15360288.2013.817500. Epub 2013 Aug 2.
Musculoskeletal conditions are common and a major cause of chronic pain; more than nine million people in the UK are affected by arthritis alone. Successful treatment of pain can lead to increased physical activity with consequent improvement of muscle tone around the affected joints. In older patients with multiple comorbidities, fewer therapeutic approaches or surgical interventions tend to be indicated. Where opioid therapy is unsuccessful, possible strategies include opioid rotation and/or changing route of administration.
肌肉骨骼疾病很常见,是慢性疼痛的主要原因;仅在英国,就有超过900万人受到关节炎的影响。成功治疗疼痛可增加身体活动,从而改善患关节周围的肌肉张力。在患有多种合并症的老年患者中,往往需要更少的治疗方法或手术干预。当阿片类药物治疗无效时,可能的策略包括阿片类药物轮换和/或改变给药途径。