Passmore Peter, Cunningham Emma
Queens University Belfast, Northern Ireland, UK.
J Pain Palliat Care Pharmacother. 2013 Aug;27(3):292-5. doi: 10.3109/15360288.2013.817502. Epub 2013 Aug 2.
Challenges to pharmacological management in this patient group include treatment concordance, comorbidity, polypharmacy, and age-related physiological changes affecting pharmacokinetics. Paracetamol (acetaminophen) is generally recommended as a first-choice analgesic in osteoarthritis pain. Topical nonsteroidal anti-inflammatory drugs (NSAIDs) should be considered ahead of oral formulations, and prescribing NSAIDs for older people requires careful consideration. There are some data relating to opioid use for noncancer pain in older people.
该患者群体在药物治疗管理方面面临的挑战包括治疗依从性、合并症、多种药物联合使用以及影响药代动力学的年龄相关生理变化。对乙酰氨基酚通常被推荐为骨关节炎疼痛的首选镇痛药。局部用非甾体抗炎药应优先于口服制剂考虑，为老年人开具非甾体抗炎药需要谨慎考虑。有一些关于老年人非癌性疼痛使用阿片类药物的数据。
