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鸟氨酸α-酮戊二酸对慢性肝病患者脑代谢的影响。

Effect of ornithine alpha oxoglutarate on brain metabolism in patients with chronic liver disease.

作者信息

James I M, Hamlyn A N, Brant P C, Hildrew P

出版信息

J Neurol Neurosurg Psychiatry. 1975 Mar;38(3):214-8. doi: 10.1136/jnnp.38.3.214.

Abstract

Patients with chronic liver disease, yet without severe encephalopathy, were found to show evidence of increased brain utilization of glucose. The changes were abolished after an intravenous infusion of 15 g ornithine alpha oxoglutarate, given over a period of 15 minutes. The possible implications of these observations are discussed.

摘要

患有慢性肝病但无严重肝性脑病的患者被发现有大脑葡萄糖利用增加的证据。在15分钟内静脉输注15克鸟氨酸α-酮戊二酸后,这些变化消失。讨论了这些观察结果可能的意义。

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本文引用的文献

6
Ammonia toxicity and cerebral oxidative metabolism.氨毒性与脑氧化代谢
Am J Physiol. 1961 Mar;200:420-4. doi: 10.1152/ajplegacy.1961.200.3.420.
7
Cerebral metabolism in hepatic insufficiency.肝功能不全时的脑代谢
Am J Med. 1956 Dec;21(6):843-9. doi: 10.1016/0002-9343(56)90098-5.

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