Department of Molecular Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Cell Stem Cell. 2013 Aug 1;13(2):133-4. doi: 10.1016/j.stem.2013.07.011.
Tet proteins and DNA demethylation are key regulators of embryonic stem cells, but their roles in development and tissue stem cells remain unclear. In this issue, Zhang et al. (2013) show that Tet1 regulates adult hippocampal neurogenesis by controlling progenitor proliferation, and Tet1 deficiency generates defects in learning and memory.
Tet 蛋白和 DNA 去甲基化是胚胎干细胞的关键调节因子，但它们在发育和组织干细胞中的作用仍不清楚。在本期杂志中，Zhang 等人（2013 年）表明 Tet1 通过控制祖细胞增殖来调节成年海马神经发生，而 Tet1 缺失会导致学习和记忆缺陷。
