Meyer U, Gerhard I, Runnebaum B
Abteilung für Gynäkologische Endokrinologie der Universitäts, Frauenklinik Heidelberg.
Geburtshilfe Frauenheilkd. 1990 Jul;50(7):542-7. doi: 10.1055/s-2008-1026298.
From March 1986 to December 1987, a vaginal contraceptive, not yet commercially available in Germany, was studied in 56 women. The substance benzalconium chloride (BZC) was contained in vaginal sponges (n = 46), pessaries (n = 4) and cream (n = 6) at a dose rate of 1.18%. BZC is a surfactant of the ammonium series that ruptures the spermatozoal membrane. It is also a powerful bactericide and viricide. The advantages of the vaginal sponge (intercourse is safe immediately after insertion for the next 24 h and for multiple intercourses) made it pleasant for the women. The rate of transitory local side effects (16%) was acceptable. The vaginal contraception did not interfere with the sexual life. In 645 months of use 10 pregnancies occurred of which 9 happened with the sponge (PI 20.3). Its fixation before the cervix and the release of the spermicide is not reliable enough, so that we cannot recommend the sponge as a safe vaginal contraceptive.
1986年3月至1987年12月，对56名女性进行了一种在德国尚未上市的阴道避孕药具的研究。阴道海绵（46例）、阴道栓（4例）和乳膏（6例）中含有苯扎氯铵（BZC），剂量率为1.18%。BZC是一种铵类表面活性剂，可破坏精子膜。它也是一种强力杀菌剂和杀病毒剂。阴道海绵的优点（插入后24小时内及多次性交后性交均安全）让女性感到满意。短暂局部副作用发生率（16%）是可以接受的。阴道避孕不干扰性生活。在645个月的使用期内发生了10次妊娠，其中9次发生在使用海绵期间（妊娠指数20.3）。其在宫颈前的固定及杀精剂的释放不够可靠，因此我们不能推荐海绵作为一种安全的阴道避孕药具。
