Steichen O, Plouin P-F
Faculté de médecine, université Pierre-et-Marie-Curie-Paris-6, 75006 Paris, France; Service de médecine interne, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 75020 Paris, France.
Faculté de médecine, université Paris Descartes, Sorbonne Paris-Cité, 75006 Paris, France; Unité d'hypertension artérielle, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75908 Paris cedex 15, France.
Rev Med Interne. 2014 Apr;35(4):235-42. doi: 10.1016/j.revmed.2013.06.013. Epub 2013 Jul 30.
Hypertension is a common health problem with serious consequences for individuals and a heavy attributable burden for populations. Reducing this burden requires preventive actions at the population level and early diagnosis at the individual level, followed by proactive interventions with proven benefits. Given the variability of blood pressure measurement, diagnosis is established only after repeated measurements under standardized conditions, if possible outside the clinic. Lifestyle changes can modestly reduce blood pressure; their impact is significant if they can be achieved on a large scale. Hypertension treatment requires a rational pharmacological approach, which can reach the target blood pressure within less than 6 months and three pharmacological classes at most in more than 80% of cases. Specialized consultation is required in the remaining 20% to detect secondary hypertensions, to optimize drug therapy and to discuss, in a minority of cases, non-pharmacological treatments. Recommendations are written by experts who select, interpret, and extrapolate the results of clinical research. As a consequence, they are sometimes unsuitable for primary care practice and frequently inconsistent across guidelines. Efforts are currently made to produce less disputable and more usable guidelines.
高血压是一个常见的健康问题,对个人有严重后果,对人群造成沉重的可归因负担。减轻这一负担需要在人群层面采取预防行动,在个体层面进行早期诊断,随后进行有已证实益处的积极干预。鉴于血压测量的变异性,只有在标准化条件下重复测量后才能确诊,如有可能应在诊所外进行。生活方式的改变可适度降低血压;如果能大规模实现,其影响将十分显著。高血压治疗需要合理的药物治疗方法,在超过80%的病例中,该方法可在不到6个月的时间内使血压达到目标水平,且最多使用三类药物。其余20%的病例需要专业会诊,以检测继发性高血压、优化药物治疗,并在少数情况下讨论非药物治疗。指南由专家撰写,他们选择、解释并推断临床研究结果。因此,这些指南有时不适用于初级保健实践,且在不同指南之间常常不一致。目前正在努力制定争议较小、更具实用性的指南。