Department of Metallurgical and Materials Engineering, Istanbul Technical University, 34469, Maslak, Istanbul, Turkey.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4337-42. doi: 10.1016/j.msec.2013.06.027. Epub 2013 Jun 28.
In this study, formation of magnesium substituted hydroxyapatite (Ca10-xMgx(PO4)6(OH)2) on (Ti,Mg)N and TiN coating surfaces were investigated. The (Ti1-x,Mgx)N (x=0.064) coatings were deposited on titanium substrates by using cathodic arc physical vapor deposition technique. TiN coated grade 2 titanium substrates were used as reference to understand the role of magnesium on hydroxyapatite (HA) formation. The HA formation experiments was carried out in simulated body fluids (SBF) with three different concentrations (1X SBF, 5X SBF and 5X SBF without magnesium ions) at 37 °C. The coatings and hydroxyapatite films formed were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD) and FTIR Spectroscopy techniques. The energy dispersive X-ray spectroscopy (EDS) analyses and XRD investigations of the coatings indicated that magnesium was incorporated in the TiN structure rather than forming a separate phase. The comparison between the TiN and (Ti, Mg)N coatings showed that the presence of magnesium in TiN structure facilitated magnesium substituted HA formation on the surface. The (Ti,Mg)N coatings can potentially be used to accelerate the HA formation in vivo conditions without any prior hydroxyapatite coating procedure.
在这项研究中，研究了在 (Ti,Mg)N 和 TiN 涂层表面上形成镁取代的羟基磷灰石 (Ca10-xMgx(PO4)6(OH)2)。通过使用阴极电弧物理气相沉积技术在钛基体上沉积了 (Ti1-x,Mgx)N (x=0.064) 涂层。TiN 涂层的 2 级钛基体用作参考，以了解镁对羟基磷灰石 (HA) 形成的作用。在 37°C 的三种不同浓度（1X SBF、5X SBF 和不含镁离子的 5X SBF）的模拟体液 (SBF) 中进行了 HA 形成实验。采用扫描电子显微镜 (SEM)、X 射线衍射 (XRD) 和傅里叶变换红外光谱 (FTIR) 技术对涂层和形成的羟基磷灰石薄膜进行了表征。涂层的能谱分析 (EDS) 和 XRD 研究表明，镁掺入了 TiN 结构中，而不是形成单独的相。TiN 和 (Ti, Mg)N 涂层的比较表明，TiN 结构中镁的存在促进了表面上镁取代的 HA 的形成。(Ti,Mg)N 涂层可潜在地用于加速体内条件下的 HA 形成，而无需进行任何预先的羟基磷灰石涂层程序。
