Gold Kathryn A, Neskey Michele, William William N
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Otolaryngol Clin North Am. 2013 Aug;46(4):645-56. doi: 10.1016/j.otc.2013.04.005. Epub 2013 May 25.
In locoregionally advanced head and neck squamous cell carcinomas, outcomes using single-modality therapy are usually poor. Although chemotherapy alone is not considered a curative therapy, the addition of chemotherapy to other modalities can lead to improved outcomes. Discussed here is the use of chemotherapy for oropharyngeal and/or oral cavity squamous cell carcinomas in 3 settings: in combination with radiation as definitive therapy, as induction treatment before definitive therapy, and in combination with radiation therapy as adjuvant treatment following surgical resection. The role of the targeted agent cetuximab in combination with radiation therapy for locally advanced disease is also discussed.
在局部区域晚期头颈部鳞状细胞癌中，采用单一疗法的治疗效果通常较差。尽管单纯化疗不被视为一种根治性疗法，但在其他治疗方式中加入化疗可改善治疗效果。本文讨论了化疗在三种情况下用于口咽和/或口腔鳞状细胞癌的应用：与放疗联合作为根治性治疗、在根治性治疗前作为诱导治疗，以及在手术切除后与放疗联合作为辅助治疗。还讨论了靶向药物西妥昔单抗联合放疗用于局部晚期疾病的作用。
