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硬皮病特异性胃肠道仪器与系统性硬化症上消化道客观受累之间的关联。

Associations between a scleroderma-specific gastrointestinal instrument and objective tests of upper gastrointestinal involvements in systemic sclerosis.

机构信息

University of California Medical Center, Los Angeles, USA.

出版信息

Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):57-63. Epub 2013 Jul 22.

PMID:23910611

Abstract

OBJECTIVES

UCLA-SCTC-GIT 2.0 is an instrument designed to evaluate gastrointestinal (GI) symptoms in systemic sclerosis (SSc). The objective of our study was to assess the associations between the upper GI (UGI) symptom scales (reflux and distention/bloating [D/B] scales) versus objective/laboratory studies.

METHODS

Fifty-five patients with SSc were enrolled at 2 centres. Each patient completed the GIT 2.0 and had objective and laboratory tests. Correlations were assessed using the Spearman's test. We also assessed the average scores in patients with positive vs. negative tests and compared them using the t-test and Wilcoxon test.

RESULTS

The mean (SD) age was 53.6 (11.8), 90% were women and 49% had limited SSc. The mean reflux and D/B scores were 0.82 and 1.25, respectively (moderate severity). The reflux scale had moderate correlations with upper GI objective evaluations (correlation coefficient ≥0.40) and was able to differentiate between patients with endoscopy proven esophagitis and manometric abnormalities (p=0.01 for both). D/B scores were numerically higher in patients with abnormal objective tests. The GIT 2.0 reflux and D/B scales had a high sensitivity ranging from 80% to 94% but very low specificity (range; 0-20%) based on objective gold standard GI measures.

CONCLUSIONS

The GIT 2.0 reflux and D/B scales have a high sensitivity (range 80-94%) for UGI involvement. The GIT 2.0 instrument complements the objective tests for assessment of the UGI.

摘要

目的

UCLA-SCTC-GIT 2.0 是一种用于评估系统性硬化症（SSc）患者胃肠道（GI）症状的工具。本研究的目的是评估上 GI（UGI）症状量表（反流和膨胀/肿胀[D/B]量表）与客观/实验室研究之间的相关性。

方法

在两个中心共招募了 55 名 SSc 患者。每位患者均完成了 GIT 2.0 问卷，并接受了客观和实验室检查。使用 Spearman 检验评估相关性。我们还评估了阳性和阴性检查患者的平均评分，并使用 t 检验和 Wilcoxon 检验进行比较。

结果

患者的平均（SD）年龄为 53.6（11.8）岁，90%为女性，49%为局限型 SSc。反流和 D/B 评分的平均值分别为 0.82 和 1.25（中度严重程度）。反流量表与上 GI 客观评估具有中度相关性（相关系数≥0.40），并且能够区分内镜证实食管炎和测压异常的患者（两者的 p 值均为 0.01）。异常客观检查患者的 D/B 评分数值更高。GIT 2.0 反流和 D/B 量表的敏感性较高，范围为 80%-94%，但特异性较低（范围为 0-20%），这是基于客观的 GI 金标准测量。