Institute of Genomic Medicine, Wenzhou Medical College, Wenzhou, China.
J Viral Hepat. 2013 Sep;20(9):602-11. doi: 10.1111/jvh.12082. Epub 2013 Mar 21.
Increasing evidence suggests that interleukin-10 (IL-10) gene promoter polymorphisms may be associated with chronic hepatitis C virus (HCV) infection and HCV clearance. To more precisely estimate the association between these variants and the risk of HCV infection, we performed a meta-analysis of 26 studies describing the IL-10-1082A/G, -819C/T, -592C/A genotypes, including 4039 chronic HCV infection cases and 2902 controls. When compared with a healthy population, the -1082GG allele had a 43% increased risk of chronic HCV infection in combined populations (GG vs GA + AA: odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.052-1.952, P = 0.023). In subgroup analysis by ethnicity, a significant increased risk was associated with the -1082GG genotype in the Caucasian population (GG vs AA: OR = 1.390, 95% CI: 1.108-1.744, P = 0.004; GG vs GA + AA: OR = 1.621, 95% CI: 1.267-2.075, P = 0.000). However, no significant association was found in Asian, African or Chinese populations. Moreover, a higher distribution of -592A was found in the spontaneously recovered population (AA vs CC: OR = 0.585, 95% CI = 0.387-0.884, P = 0.011; AA + AC vs CC: OR = 0.738, 95% CI = 0.551-0.988, P = 0.041; AA vs AC + CC: OR = 0.788, 95% CI = 0.664-0.935, P = 0.006) than that in the chronic HCV infection population. In conclusion, the IL-10-1082GG allele may increase the risk of chronic HCV infection in Caucasian population, and people carrying the IL-10-592A allele are more likely to clear HCV spontaneously.
越来越多的证据表明，白细胞介素-10（IL-10）基因启动子多态性可能与慢性丙型肝炎病毒（HCV）感染和 HCV 清除有关。为了更准确地估计这些变体与 HCV 感染风险之间的关系，我们对 26 项描述 IL-10-1082A/G、-819C/T、-592C/A 基因型的研究进行了荟萃分析，包括 4039 例慢性 HCV 感染病例和 2902 例对照。与健康人群相比，联合人群中 -1082GG 等位基因患慢性 HCV 感染的风险增加了 43%（GG 与 GA+AA：比值比（OR）=1.433，95%置信区间（CI）=1.052-1.952，P=0.023）。按种族亚组分析，高加索人群中 -1082GG 基因型与显著的高风险相关（GG 与 AA：OR=1.390，95%CI：1.108-1.744，P=0.004；GG 与 GA+AA：OR=1.621，95%CI：1.267-2.075，P=0.000）。然而，在亚洲、非洲或中国人群中未发现显著相关性。此外，在自发恢复人群中发现 -592A 的分布较高（AA 与 CC：OR=0.585，95%CI=0.387-0.884，P=0.011；AA+AC 与 CC：OR=0.738，95%CI=0.551-0.988，P=0.041；AA 与 AC+CC：OR=0.788，95%CI=0.664-0.935，P=0.006）。总之，IL-10-1082GG 等位基因可能会增加高加索人群患慢性 HCV 感染的风险，而携带 IL-10-592A 等位基因的人更有可能自发清除 HCV。
