Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.
Curr Opin Struct Biol. 2013 Oct;23(5):695-703. doi: 10.1016/j.sbi.2013.07.008. Epub 2013 Jul 30.
Growth and maintenance of the protective peptidoglycan cell wall are vital to bacterial growth and morphogenesis. Thus, the relative rate and spatiotemporal control of the synthesis and degradation of this net-like polymer defines bacterial cell shape. In recent years, our understanding of the processes that govern this delicate metabolic balance has improved and should lend insight into how to therapeutically target the system in the future.
肽聚糖细胞壁的生长和维持对细菌的生长和形态发生至关重要。因此，这种网状聚合物的合成和降解的相对速率和时空控制决定了细菌的细胞形状。近年来，我们对控制这种微妙代谢平衡的过程的理解有所提高，这应该有助于我们了解未来如何对该系统进行治疗性靶向。
