碱性液输注对呼吸窘迫综合征婴儿的即刻影响。
Immediate effects of alkaline infusion in infants with respiratory distress syndrome.
作者信息
Baum J D, Robertson N R
出版信息
J Pediatr. 1975 Aug;87(2):255-61. doi: 10.1016/s0022-3476(75)80597-x.
Nineteen infants with acidosis associated with RDS were studied following the infusion of: (1) 0.58M (7%) THAM over 30 seconds; (2) molar bicarbonate over 30 seconds; (3) molar bicarbonate over 2 minutes; and (4) molar bicarbonate over 5 minutes. PaC02 fell after THAM; PaC02 rose sharply after bicarbonate and remained elevated 10 minutes after infusion. The pH rose abruptly in all infants and remained significantly elevated 10 minutes after infusion. Pa02 changes were variable; no infant had immediate improvement in Pa02. The changes in osmolality, hematocrit, and colloid osmotic pressure describe the immediate osmotic hemodilution following the infusion of hypertonic base.
对19例患有与呼吸窘迫综合征相关酸中毒的婴儿进行了以下输注后的研究：（1）在30秒内输注0.58M（7%）三羟甲基氨基甲烷（THAM）；（2）在30秒内输注等摩尔碳酸氢盐；（3）在2分钟内输注等摩尔碳酸氢盐；（4）在5分钟内输注等摩尔碳酸氢盐。输注THAM后动脉血二氧化碳分压（PaC02）下降；输注碳酸氢盐后PaC02急剧上升，并在输注后10分钟内持续升高。所有婴儿的pH值均突然升高，并在输注后10分钟内仍显著升高。动脉血氧分压（Pa02）变化不定；没有婴儿的Pa02立即改善。输注高渗碱后，渗透压、血细胞比容和胶体渗透压的变化描述了即刻的渗透性血液稀释情况。
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