Wei Y, Hang Z
Hua Xi Yi Ke Da Xue Xue Bao. 1990 Jun;21(2):193-6.
The clinicopathologic and ultrastructural studies of 12 cases of olfactory neuroblastoma were made. The ages of patients ranged from 2 to 58 years with a mean of 32. Eleven cases occurred in men and 1 case in woman. An acidophilic fibrillary intercytoplasmic background was present in every case. Its amount varied focally. Ultrastructurally, the acidophilic fibrillary background was composed of neuronal cell processes. Homer-Wright rosettes were found in 7 cases, Flexner type rosettes in 4 cases, 3 of which shared both Homer-Wright and Flexner type rosettes. Almost all cases with rosettes also had apparent acidophilic fibrillary intercytoplasmic background. So, we think that acidophilic fibrillary intercytoplasmic background was the most useful diagnostic feature by light microscopic observation. The diagnosis of olfactory neuroblastoma by electron microscopy was mainly based on neuronal processes, neurosecretory granules, microtubules, neurofilaments, synaptic-like junctions and occasionally both microvilli and olfactory vesicles at the luminal borders of Flexner type rosettes.
对12例嗅神经母细胞瘤进行了临床病理及超微结构研究。患者年龄从2岁至58岁不等，平均年龄为32岁。男性11例，女性1例。每例均存在嗜酸性纤维性胞质内背景，其数量局部有所不同。超微结构上，嗜酸性纤维性背景由神经细胞突起组成。7例发现有霍纳 - 赖特菊形团，4例发现有弗莱克斯纳型菊形团，其中3例同时具有霍纳 - 赖特和弗莱克斯纳型菊形团。几乎所有有菊形团的病例也都有明显的嗜酸性纤维性胞质内背景。因此，我们认为嗜酸性纤维性胞质内背景是光镜观察最有用的诊断特征。嗅神经母细胞瘤的电镜诊断主要基于神经突起、神经分泌颗粒、微管、神经丝、突触样连接，偶尔还基于弗莱克斯纳型菊形团管腔边界处的微绒毛和嗅泡。
