Department of Pharmacology, University of Extremadura, Cáceres, Spain.
Hum Immunol. 2013 Dec;74(12):1705-8. doi: 10.1016/j.humimm.2013.07.008. Epub 2013 Jul 31.
BACKGROUND/OBJECTIVES: Some experimental data suggest a possible role of tau protein in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis. The aim of this study was to investigate a possible influence of the SNP rs1052553 in the MAPT gene in the risk for relapsing bout onset (relapsing-remitting and secondary progressive) MS.
We analyzed the allelic and genotype frequency of MAPT rs1052553, which has been associated with some neurodegenerative diseases, in 259 patients with relapsing bout onset MS and 291 healthy controls, using TaqMan Assays.
MAPT rs1052553 allelic and genotype frequencies did not differ significantly between relapsing bout onset MS patients and controls, and were unrelated with the age of onset of MS or gender.
These results suggest that MAPT rs1052553 polymorphism is not related with the risk for relapsing bout onset MS.
背景/目的：一些实验数据表明，tau 蛋白可能在多发性硬化症（MS）的发病机制以及实验性自身免疫性脑脊髓炎中发挥作用。本研究旨在探讨 MAPT 基因中 SNP rs1052553 对复发性发作（复发缓解型和继发进展型）MS 的发病风险的可能影响。
我们使用 TaqMan 分析方法，分析了与某些神经退行性疾病相关的 MAPT rs1052553 在 259 例复发性发作 MS 患者和 291 例健康对照者中的等位基因和基因型频率。
MAPT rs1052553 的等位基因和基因型频率在复发性发作 MS 患者和对照组之间无显著差异，且与 MS 的发病年龄或性别无关。
这些结果表明，MAPT rs1052553 多态性与复发性发作 MS 的发病风险无关。
