Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Neuroscience. 2013 Oct 10;250:658-63. doi: 10.1016/j.neuroscience.2013.07.059. Epub 2013 Aug 2.
Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.
某些模式的神经活动可以诱导 N-甲基-D-天冬氨酸受体（NMDAR）依赖性突触可塑性，这是记忆的重要基础之一。在这里，我们报告说，一种模式化的高频刺激（PHS）以一种不依赖于 NMDAR 的方式诱导大鼠海马体的长时程抑制（LTD），这种方式需要 GABAAR 和毒蕈碱型乙酰胆碱受体（mAChR）的共激活以及 AMPAR 的内吞作用。因此，我们揭示了一种模式化的高频刺激可以在海马体中引发 GABAAR 和 mAChR 依赖性 LTD。
