合成及吡喹酮衍生物对日本血吸虫活性的 SAR 研究。
Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum.
机构信息
School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.
出版信息
Molecules. 2013 Jul 31;18(8):9163-78. doi: 10.3390/molecules18089163.
Abstract
The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
摘要
描述了具有抗日本血吸虫成虫活性的吡喹酮衍生物的合成及构效关系（SAR）研究。其中一些化合物的杀蠕虫活性优于吡喹酮，可作为进一步优化的先导化合物。
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