Ryser J E, Carrel S, Buchegger F, Donath A
Division of Nuclear Medicine, University Hospital of Geneva, Switzerland.
Int J Rad Appl Instrum B. 1990;17(5):495-7. doi: 10.1016/0883-2897(90)90169-2.
The biodistribution of 75Se and 125I were compared in nude mice bearing melanomas and injected simultaneously with biosynthetically-labeled 75Se-MoAbs and radioiodinated 125I-MoAbs from the same anti-melanoma hybridoma. The 75Se dose recovery in the tumor (day 10) was twice that for 125I, but the tumor to normal tissue ratios were identical. It is concluded that biosynthetically-labeled MoAbs survive better in vivo, while the tumor to normal tissue ratios are governed by the excretion rate of labeled MoAb catabolytic products.
在荷黑色素瘤的裸鼠中比较了75Se和125I的生物分布，这些裸鼠同时注射了来自同一抗黑色素瘤杂交瘤的生物合成标记的75Se单克隆抗体（MoAbs）和放射性碘化的125I - MoAbs。肿瘤中75Se剂量回收率（第10天）是125I的两倍，但肿瘤与正常组织的比率相同。得出的结论是，生物合成标记的MoAbs在体内存活得更好，而肿瘤与正常组织的比率由标记的MoAb分解代谢产物的排泄率决定。
