使用¹²⁵I - HIPDM研究环孢素A对大鼠的毒性作用所引起的组织反应。

The use of 125I-HIPDM for studying tissue response due to toxic effects of cyclosporin-A in rats.

作者信息

Owunwanne A, Shihab-Eldeen A, Sadek S, Yacoub T, Hussain A, Abdel-Dayem H M

机构信息

Department of Nuclear Medicine, Faculty of Medicine, Kuwait University.

出版信息

Int J Rad Appl Instrum B. 1990;17(5):507-9. doi: 10.1016/0883-2897(90)90171-v.

DOI:10.1016/0883-2897(90)90171-v

PMID:2391246

Abstract

125I-HIPDM was used to study the response of various tissues in cyclosporin-A, CyA, treated and control rats. The rats were given 50 mg/kg of CyA for 7 consecutive days. The liver, kidney and heart showed significant increase while the spleen had a pronounced decrease in the uptake of 125I-HIPDM in CyA treated compared to control rats. This difference in the uptake of 125I-HIPDM between CyA treated and control rats is assumed to be the tissue response to toxic effects of CyA. The results indicate that CyA is toxic to liver, kidney, spleen and probably heart. There was no difference in the uptake of 125I-HIPDM in the lung and brain of CyA treated and control rats. This lack of difference is assumed to indicate that CyA does not adversely affect the lung and brain.

摘要

采用¹²⁵I-碘代苯异丙胺（¹²⁵I-HIPDM）研究环孢素A（CyA）处理组大鼠和对照组大鼠各组织的反应。大鼠连续7天给予50mg/kg的CyA。与对照组大鼠相比，CyA处理组大鼠的肝脏、肾脏和心脏对¹²⁵I-HIPDM的摄取显著增加，而脾脏摄取明显减少。CyA处理组和对照组大鼠对¹²⁵I-HIPDM摄取的这种差异被认为是组织对CyA毒性作用的反应。结果表明，CyA对肝脏、肾脏、脾脏可能还有心脏具有毒性。CyA处理组和对照组大鼠肺和脑中¹²⁵I-HIPDM的摄取没有差异。这种无差异被认为表明CyA对肺和脑没有不利影响。