Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
Wien Klin Wochenschr. 2013 Sep;125(17-18):537-40. doi: 10.1007/s00508-013-0408-1. Epub 2013 Aug 3.
The Interferon (IFN) which is the standard treatment for Hepatitis C, may cause a lot of side effects including dermatological anomalies. This paper presents a psoriasis case which occurred in relation with the treatment of acute hepatitis C (AHC) with peginterferon alfa (peg-IFN-α). A 60-year-old male patient came to the hospital with symptoms of high liver enzymes. The patient with history of a recent operation showed anti-HCV(+), HCVRNA 3.5 million IU/mL and HCV genotype 1b in the tests. Without any other etiological factors found in the patient, we started a treatment of peg-IFNα-2b with the diagnosis of AHC. After 3 weeks, psoriatic plaques were observed in various parts of the body. Antiviral treatment of the patient was concluded within 6 months. His psoriasis treatment initially commenced with local agents followed by phototherapy. Permanent viral response was seen in the patient and his lesions recovered rapidly after the antipsoriatic and antiviral treatment. Psoriasis and other autoimmune diseases should be considered even though they are encountered rarely,and the patients should be informed of the possible risks before planning treatment with peg-IFN-α.
干扰素（IFN）是丙型肝炎的标准治疗方法，但可能会引起许多副作用，包括皮肤异常。本文报告了一例因使用聚乙二醇干扰素α（peg-IFN-α）治疗急性丙型肝炎（AHC）而出现银屑病的病例。一名 60 岁男性患者因高肝酶就诊。该患者有近期手术史，检查显示抗 HCV（+）、HCVRNA 为 350 万 IU/mL 和 HCV 基因型 1b。在患者中未发现其他病因，我们开始用 peg-IFNα-2b 治疗，诊断为 AHC。3 周后，患者身体各处出现银屑病斑块。由于 6 个月内未发现任何其他病因，我们结束了抗病毒治疗。患者的银屑病治疗最初采用局部药物治疗，然后进行光疗。患者获得了持久的病毒应答，抗银屑病和抗病毒治疗后，他的皮损迅速恢复。即使在罕见的情况下也应考虑银屑病和其他自身免疫性疾病，在计划使用 peg-IFN-α 治疗之前，应告知患者可能存在的风险。
