Bander Neil H
Weill-Cornell Medical College, Cornell University, New York, NY, USA.
Methods Mol Biol. 2013;1045:29-40. doi: 10.1007/978-1-62703-541-5_2.
ADC success requires that all three components of the agent function in a near-flawless manner. Equally important is that the target be selected with stringent consideration as the target is the one factor in ADC development that is immutable and beyond the reach of the developer to refine/manipulate. This chapter reviews the critical factors of target selection that must be met if one is to succeed at ADC development.
抗体药物偶联物（ADC）的成功需要其所有三个组成部分都能近乎完美地发挥作用。同样重要的是，必须严格谨慎地选择靶点，因为靶点是ADC开发中唯一不可改变且开发者无法优化/操控的因素。本章回顾了若要在ADC开发中取得成功必须满足的靶点选择关键因素。
