Department of Pathology, Samsung Changwon Hospital, School of Medicine, Sungkyunkwan University, Changwon, South Korea.
Virchows Arch. 2013 Oct;463(4):489-95. doi: 10.1007/s00428-013-1461-x. Epub 2013 Aug 4.
Heat shock protein 70 (HSP70) is a molecular chaperone which plays an important role in cellular protection against various stressful stimuli and in the regulation of cellular growth and apoptosis. This study was conducted in gastric carcinoma (GC) to assess correlations of HSP70 expression with clinicopathological parameters and overall survival (OS). Tissue microarray blocks were constructed from 172 GCs and immunohistochemically stained for HSP70. Low HSP70 expression was found in 122 GCs (71 %), whereas 50 (29 %) had high expression. HSP70 expression was higher in tumours in the cardia (p = 0.008), with non-signet ring cell histology (p < 0.001), of intestinal type (p = 0.045) and of higher pathological T stage (p = 0.026). When considering the cohort as a whole, HSP70 expression did not correlate with OS (p = 0.092). In intestinal type carcinomas, however, high HSP70 expression significantly correlated with worse OS (p = 0.034). These results suggest that HSP70 expression might be an unfavourable prognostic factor in patients with GC, especially of intestinal type.
热休克蛋白 70（HSP70）是一种分子伴侣，在细胞对抗各种应激刺激以及调节细胞生长和凋亡方面发挥着重要作用。本研究在胃癌（GC）中进行，旨在评估 HSP70 表达与临床病理参数和总生存期（OS）的相关性。从 172 例 GC 中构建组织微阵列块，并对 HSP70 进行免疫组织化学染色。结果发现，122 例 GC（71%）中 HSP70 表达较低，50 例（29%）表达较高。HSP70 在贲门肿瘤（p=0.008）、非印戒细胞组织学（p<0.001）、肠型（p=0.045）和较高的病理 T 分期（p=0.026）中表达较高。当考虑整个队列时，HSP70 表达与 OS 无相关性（p=0.092）。然而，在肠型癌中，HSP70 表达较高与较差的 OS 显著相关（p=0.034）。这些结果表明，HSP70 表达可能是 GC 患者的一个不利预后因素，尤其是肠型。
