Division of Nephrology, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Eur J Pediatr. 2013 Dec;172(12):1687-92. doi: 10.1007/s00431-013-2113-5. Epub 2013 Aug 3.
Recent findings suggest that low-birth-weight children with current obesity are more likely to have higher systolic blood pressure levels and impaired β-cell function than those who are obese with normal birth weight. It seems possible, however, that concurrent low birth weight with excess weight gain can exacerbate other risk factors for cardiometabolic diseases. The purpose of this study is to investigate the influence of birth weight on the lipid/apolipoprotein profile, visfatin levels, and insulin parameters in overweight/obese children. A cross-sectional study of 68 overweight/obese children was conducted. Among these children, 28 were identified with low birth weight and 40 were of normal birth weight. Blood lipid profile, apolipoproteins, visfatin, glucose, and insulin were measured. Our results show that systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, triglycerides (TG), very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc), apolipoprotein B and E, insulin, apolipoprotein B/A1 ratio, and homeostasis model assessment insulin resistance (HOMA-IR) were significantly elevated in overweight/obese low-birth-weight (LBW) children. There was a significant association of the SBP levels with TG (P=0.027), LDLc (P=0.001), HOMA-IR (P<0.001), apolipoprotein B (P=0.001), and apolipoprotein E (P=0.039).
Our findings suggest that LBW children with overweight or obesity have an additional risk factor for both atherogenic and insulinogenic profile.
最近的研究结果表明，与出生体重正常但肥胖的儿童相比，目前肥胖且出生体重较低的儿童更有可能出现收缩压升高和β细胞功能受损。然而，似乎同时存在低出生体重和体重过度增加会加剧其他心血管代谢疾病的风险因素。本研究旨在探讨出生体重对超重/肥胖儿童血脂/载脂蛋白谱、内脂素水平和胰岛素参数的影响。对 68 名超重/肥胖儿童进行了横断面研究。这些儿童中，28 名出生体重低，40 名出生体重正常。测量了血脂谱、载脂蛋白、内脂素、血糖和胰岛素。我们的结果表明，超重/肥胖低出生体重（LBW）儿童的收缩压（SBP）和舒张压（DBP）水平、甘油三酯（TG）、极低密度脂蛋白胆固醇、低密度脂蛋白胆固醇（LDLc）、载脂蛋白 B 和 E、胰岛素、载脂蛋白 B/A1 比值和稳态模型评估胰岛素抵抗（HOMA-IR）显著升高。SBP 水平与 TG（P=0.027）、LDLc（P=0.001）、HOMA-IR（P<0.001）、载脂蛋白 B（P=0.001）和载脂蛋白 E（P=0.039）显著相关。
我们的研究结果表明，超重或肥胖的 LBW 儿童存在动脉粥样硬化和胰岛素生成双重危险因素。
