Bernecker C, Hartung B, Maser-Gluth C, Schott M, Willenberg H S
Klinik für Endokrinologie und Diabetologie, Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Dtsch Med Wochenschr. 2013 Aug;138(33):1659-63. doi: 10.1055/s-0033-1343341. Epub 2013 Aug 2.
HISTORY AND INITIAL FINDINGS: In a 75-year-old woman with unclear weight gain and typical signs of Cushing's syndrome, a pituitary microadenoma and hyperplasia of the left adrenal gland were diagnosed. She was referred for preoperative diagnostics. Her clinical appearance suggested hypercortisolism.
The lab test suggested external glucocorticoid application. Basal ACTH and cortisol were low. DIAGNOSIS, TREATMENT AND FURTHER COURSE: The patients' phytotherapeutics received from a masseuse were analyzed in a special lab. The analysis showed that the pills were enriched with cortisone and hydrocortisone and were causal for the development of Cushing's syndrome and the symptoms of secondary adrenal insufficiency.
Symptoms of Cushing's syndrome develop during chronic exposure to glucocorticoids. The development of Cushing's syndrome depends on the patient's sensitivity and on the duration and dose of the glucocorticoid application. Clinical and laboratory studies precede imaging.
病史及初始检查结果:一名75岁女性体重增加原因不明且有库欣综合征的典型体征,诊断为垂体微腺瘤和左肾上腺增生。她被转诊进行术前诊断。其临床表现提示皮质醇增多症。
实验室检查提示外用糖皮质激素。基础促肾上腺皮质激素(ACTH)和皮质醇水平较低。
诊断、治疗及后续病程:对患者从一名按摩师处接受的植物疗法药物在一个特殊实验室进行了分析。分析表明这些药丸富含可的松和氢化可的松,是导致库欣综合征及继发性肾上腺功能不全症状的原因。
库欣综合征的症状在长期接触糖皮质激素期间出现。库欣综合征的发生取决于患者的敏感性以及糖皮质激素应用的持续时间和剂量。临床和实验室研究先于影像学检查。