Essien E E, Cowan D A, Beckett A H
J Pharm Pharmacol. 1975 May;27(5):334-42. doi: 10.1111/j.2042-7158.1975.tb09451.x.
The solid inlet mass spectra of the N-oxide and N-oxide sulphoxide metabolites of promazine, chlorpromazine and methotrimeprazine have been determined at different temperatures and compared with the mass spectra of the main thermolytic product of the N-oxides and N-oxide sulphoxides obtained during combined gas chromatography-mass spectrometry. Diagnostic ions were produced by direct insertion of the compounds at ambient temperature into the mass spectrometer. These ions distinguish the N-oxides of arylalkyl tertiary amines from the N-oxygenated derivatives of primary and secondary arylalkylamines.
已在不同温度下测定了丙嗪、氯丙嗪和甲氧异丁嗪的N-氧化物及N-氧化物亚砜代谢物的固体进样质谱，并将其与在气相色谱-质谱联用过程中获得的N-氧化物及N-氧化物亚砜的主要热解产物的质谱进行了比较。通过在室温下将化合物直接插入质谱仪中产生诊断离子。这些离子可将芳基烷基叔胺的N-氧化物与伯、仲芳基烷基胺的N-氧化衍生物区分开来。
