Kawamura Akio, Kigasawa Hideaki, Kamma Hiroshi
Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
J Invasive Cardiol. 2013 Aug;25(8):E167-8.
An 83-year-old man died of aspiration pneumonia 5 months after closure of atrial septal defect (ASD) with an Amplatzer atrial septal defect occluder (ASO). At autopsy, the device was scarcely covered by the endothelium. After percutaneous ASD closure, 6-month course of antiplatelet therapy and prophylaxis for endocarditis are recommended. However, the 6-month duration may not be sufficient for some patients. More data are required to clarify how long it takes for the ASO device to be endothelialized in the human body and to determine predictors of poor endothelialization.
一名83岁男性在使用Amplatzer房间隔缺损封堵器（ASO）关闭房间隔缺损（ASD）5个月后死于吸入性肺炎。尸检时，该装置几乎未被内皮覆盖。经皮ASD封堵术后，建议进行6个月的抗血小板治疗和心内膜炎预防。然而，6个月的疗程对一些患者可能并不足够。需要更多数据来阐明ASO装置在人体内内皮化所需的时间，并确定内皮化不良的预测因素。
