MD Division of Nephrology, Stanford University School of Medicine, 777 Welch Road, Suite DE, Room D100, Palo Alto, CA 94304.
J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):315-22. doi: 10.1093/gerona/glt109. Epub 2013 Aug 2.
Evidence has recently been building that the presence of chronic kidney disease (CKD) is an independent contributor to decline in physical and cognitive functions in older adults. CKD affects 45% of persons older than 70 years of age and can double the risk for physical impairment, cognitive dysfunction, and frailty. To increase awareness of this relatively new concept of CKD as a risk factor for accelerated aging, we review studies on the association of CKD with physical function, frailty, and cognitive function. We also present a summary of the proposed mechanisms for these associations.
最近有证据表明，慢性肾脏病（CKD）的存在是导致老年人身体和认知功能下降的一个独立因素。CKD 影响着 70 岁以上人群的 45%，并且会使身体损伤、认知功能障碍和虚弱的风险增加一倍。为了提高人们对 CKD 作为加速衰老的风险因素这一相对较新的概念的认识，我们回顾了 CKD 与身体功能、虚弱和认知功能相关的研究。我们还总结了这些关联的潜在机制。
