a School of Life Sciences , Jawaharlal Nehru University , New Delhi , India.
Nutr Cancer. 2013;65(7):991-1001. doi: 10.1080/01635581.2013.814800. Epub 2013 Aug 5.
Cancer chemoprevention is a dietary or therapeutic strategy to prevent, suppress, or delay carcinogenesis either at initiation or progression level with nontoxic agents. Use of natural dietary compounds has been a major chemopreventive approach to modulate tumorigenic pathways. In the present study, we have evaluated Lagenaria siceraria (bottle gourd), a common vegetable of Indian household for its chemomodulatory potential. The fruit has been used in traditional medicine for a very long time for health benefits and to cure pain, ulcers, fever, cough, asthma, and other bronchial disorders. However, despite its reported beneficial effect the chemo modulatory potential of this plant has not been reported. Therefore chemopreventive effect of bottle gourd juice (BGJ) was studied against 7,12-dimethylbenz(a)anthracene (DMBA) plus croton oil induced skin papillomagenesis in Swiss albino mice. The effect was studied both at antiinitiation and antiinitiation/promotion level followed by histopathological study. A dose of 2.5% and 5% given in drinking water showed significant decrease in papilloma number, papilloma incidence, papilloma multiplicity, papilloma latency, papilloma volume, and papilloma size in different size range. Histopathological study showed chemopreventive effect by minimizing loss of stratification, a decrease in number of epithelial layers, reducing dermal infiltration and protection for various cytoplasmic changes. Higher dose of BGJ was found to be more effective than lower dose and the chemopreventive effect was maximum for antiinitiation/promotion treatment. Altogether, this study reports the chemopreventive effect of Lagenaria siceraria on skin papillomagenesis for the first time and suggests that its consumption may help in suppression of skin cancer.
癌症化学预防是一种通过使用非毒性物质在起始或进展水平上预防、抑制或延迟致癌作用的饮食或治疗策略。使用天然膳食化合物一直是调节肿瘤发生途径的主要化学预防方法。在本研究中，我们评估了印度家庭常见蔬菜苦瓜（Lagenaria siceraria）的化学调节潜力。苦瓜在传统医学中已经使用了很长时间，用于促进健康和治疗疼痛、溃疡、发烧、咳嗽、哮喘和其他支气管疾病。然而，尽管有报道称其具有有益的效果，但这种植物的化学调节潜力尚未得到报道。因此，研究了苦瓜汁（BGJ）对 7,12-二甲基苯并（a）蒽（DMBA）加巴豆油诱导的瑞士白化小鼠皮肤乳头瘤形成的化学预防作用。在进行组织病理学研究的同时，研究了其在抗起始和抗起始/促进水平的作用。在饮用水中给予 2.5%和 5%的剂量可显著减少肿瘤数量、肿瘤发生率、肿瘤多发性、肿瘤潜伏期、肿瘤体积和不同大小范围内的肿瘤大小。组织病理学研究表明，通过最小化分层损失、减少上皮层数量、减少真皮浸润以及保护各种细胞质变化，具有化学预防作用。发现较高剂量的 BGJ 比低剂量更有效，并且在抗起始/促进治疗中具有最大的化学预防作用。总的来说，这项研究首次报道了苦瓜对皮肤乳头瘤形成的化学预防作用，并表明其消费可能有助于抑制皮肤癌。
