Ikeda Y, Okuyama S, Fujiki Y, Tomoda K, Ohshiro K, Itoh T, Yamauchi T
Department of Psychiatry, School of Medicine, Fujita Health University, Aichi, Japan.
J Neural Transm Suppl. 1990;30:25-32. doi: 10.1007/978-3-7091-3345-3_3.
Acetylcholine (ACh) and choline (Ch) in cerebrospinal fluid from 29 normal volunteers and 7 patients with Alzheimer-type dementia (DAT) were examined using high-performance liquid chromatography with electrochemical detector coupled with liquid cation-exchange method. In normal volunteers, ACh concentration was decreased significantly from 40-50 years and Ch concentration was increased significantly from 50-60 years. CSF from patients with DAT revealed high Ch concentration and the increase was statistically significant while ACh concentration in CSF of DAT did not show a significant difference with that of normal volunteers. This Ch augmentation may suggest a disturbance in utilization of Ch for ACh synthesis and may become an useful indicator for organic changes in central cholinergic system.
