Tohgi H, Abe T, Hashiguchi K, Saheki M, Takahashi S
Department of Neurology, Iwate Medical University, Morioka, Japan.
Neurosci Lett. 1994 Aug 15;177(1-2):139-42. doi: 10.1016/0304-3940(94)90064-7.
We determined the concentrations of acetylcholine (ACh) and choline (Ch) in the cerebrospinal fluid (CSF) of patients with Alzheimer type dementia (ATD) in comparison with controls. The ACh concentration was reduced significantly and remarkably (73%, P < 0.0002) in ATD patients and had a significant positive correlation with dementia scale scores (r = 0.82, P < 0.05). The Ch concentration was unaltered in ATD patients. These results suggest that the progressive reduction in ACh in the ATD brain may be reflected in its concentrations in the CSF.
我们测定了阿尔茨海默型痴呆（ATD）患者脑脊液（CSF）中乙酰胆碱（ACh）和胆碱（Ch）的浓度，并与对照组进行比较。ATD患者的ACh浓度显著降低（73%，P < 0.0002），且与痴呆量表评分呈显著正相关（r = 0.82，P < 0.05）。ATD患者的Ch浓度未发生改变。这些结果表明，ATD大脑中ACh的逐渐减少可能反映在CSF中的浓度上。
