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与游离桡侧前臂皮瓣相比,采用鼻唇沟皮瓣对罕见双侧口腔黏膜下纤维化进行重建治疗的随机前瞻性试验。

Reconstructive management of the rare bilateral oral submucos fibrosis using nasolabial flap in comparison with free radial forearm flap--a randomised prospective trial.

作者信息

Faisal Muhammad, Rana Madiha, Shaheen Anjum, Warraich Riaz, Kokemueller Horst, Eckardt André Michael, Gellrich Nils-Claudius, Rana Majeed

出版信息

Orphanet J Rare Dis. 2013 Apr 8;8:56. doi: 10.1186/1750-1172-8-56.

Abstract

Oral sub mucous fibrosis is a rare chronic, progressive, pre malignant collagen disorder of oral mucosa in people of Asian descent characterized by trismus, blanching and stiffness of mucosa, burning sensation in mouth and hypomobility of soft palate and tongue with loss of gustatory sensation. Betel nut chewing is the most common etiological agent. Surgery remains the main stay in severe cases and aims at release of fibrotic bands and resurfacing the raw areas with different options. Reconstruction can be done by using nasolabial flap or radial free forearm flap. The purpose of this study was to compare the mouth opening after the reconstruction with either nasolabial flap or radial free forearm flap.METHODS This study was carried out on fifty (50) patients with oral sub mucous fibrosis. Twenty five (25) of these were reconstructed by nasolabial flap and twenty five (25) were reconstructed by radial free forearm flap. At different intervals of their post-operative visits, they were evaluated for the interincisal distance and the difference between the two groups was assessed.RESULTS Average increase in interincisal distance was greater in patients reconstructed with radial free forearm flap compared with patient reconstructed by nasolabial flap i.e. 18.96 mm and 15.16 mm respectively with 'P' value > 0.05.CONCLUSIONS Based on the results of this study, there was no significant difference in mouth opening after reconstruction with radial forearm free flap compared to nasolabial flap [corrected].

摘要

口腔黏膜下纤维化是一种罕见的慢性、进行性、口腔黏膜的癌前胶原紊乱疾病,发生于亚洲裔人群,其特征为牙关紧闭、黏膜变白和僵硬、口腔烧灼感、软腭和舌活动度降低以及味觉丧失。嚼槟榔是最常见的病因。在严重病例中,手术仍然是主要治疗方法,旨在松解纤维化带并用不同方法修复创面。可使用鼻唇瓣或桡侧游离前臂瓣进行重建。本研究的目的是比较采用鼻唇瓣或桡侧游离前臂瓣重建后的开口度。方法:本研究对50例口腔黏膜下纤维化患者进行。其中25例采用鼻唇瓣重建,25例采用桡侧游离前臂瓣重建。在术后不同随访时间点,评估他们的切牙间距离,并评估两组之间的差异。结果:与采用鼻唇瓣重建的患者相比,采用桡侧游离前臂瓣重建的患者切牙间距离平均增加更大,分别为18.96毫米和15.16毫米,“P”值>0.05。结论:基于本研究结果,与鼻唇瓣相比,采用桡侧游离前臂瓣重建后开口度无显著差异[校正后] 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a04c/3717039/8f8f0cd04dba/1750-1172-8-56-1.jpg

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