HIG2 通过缺氧依赖和非依赖途径促进结直肠癌进展。
HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways.
机构信息
Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, United States.
出版信息
Cancer Lett. 2013 Dec 1;341(2):159-65. doi: 10.1016/j.canlet.2013.07.028. Epub 2013 Aug 2.
Abstract
HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.
摘要
HIG2（缺氧诱导基因 2）是缺氧的生物标志物，在多种癌症中升高。在这里，我们表明 HIG2 在缺氧条件下还上调 HIF-1α 的表达，并在常氧条件下增强 AP-1 的表达，从而影响结直肠癌细胞的存活。重要的是，HIG2 的过表达通过抑制小鼠原位模型中的细胞凋亡促进肿瘤生长。由于我们发现 HIG2 的表达随着肿瘤的进展逐渐升高，因此这些结果可能与人类疾病相关。总之，这些发现表明 HIG2 以缺氧依赖和非依赖的方式在促进结直肠癌细胞生长中发挥重要作用。
相似文献
1
HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways.HIG2 通过缺氧依赖和非依赖途径促进结直肠癌进展。
Cancer Lett. 2013 Dec 1;341(2):159-65. doi: 10.1016/j.canlet.2013.07.028. Epub 2013 Aug 2.
2
Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer.缺氧诱导因子-1调节结直肠癌中mutT同源物-1的上调。
World J Gastroenterol. 2015 Dec 28;21(48):13447-56. doi: 10.3748/wjg.v21.i48.13447.
3
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.缺氧诱导蛋白 2 是一种新型的脂滴蛋白，也是缺氧诱导因子-1 的一个特异性靶基因。
FASEB J. 2010 Nov;24(11):4443-58. doi: 10.1096/fj.10-159806. Epub 2010 Jul 12.
4
The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer.SLC34A2-ROS-HIF-1 诱导的 EZH2 表达上调促进结直肠癌细胞的增殖和化疗耐药性及抗凋亡作用。
Biosci Rep. 2019 May 21;39(5). doi: 10.1042/BSR20180268. Print 2019 May 31.
5
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.缺氧诱导因子（HIF）-1对环氧合酶-2的直接转录上调促进结直肠肿瘤细胞存活，并在缺氧期间增强HIF-1转录活性。
Cancer Res. 2006 Jul 1;66(13):6683-91. doi: 10.1158/0008-5472.CAN-06-0425.
6
Myocyte enhancer factor 2D promotes colorectal cancer angiogenesis downstream of hypoxia-inducible factor 1α.肌细胞增强因子 2D 通过缺氧诱导因子 1α 促进结直肠癌血管生成。
Cancer Lett. 2017 Aug 1;400:117-126. doi: 10.1016/j.canlet.2017.04.037. Epub 2017 May 4.
7
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.硒蛋白2通过AMPK介导的脯氨酰羟化酶调节来抑制缺氧诱导因子-1α的积累。
Free Radic Biol Med. 2016 Dec;101:511-523. doi: 10.1016/j.freeradbiomed.2016.11.014. Epub 2016 Nov 11.
8
Role of Hypoxia-inducible factor-1 alpha and Survivin in colorectal carcinoma progression.缺氧诱导因子-1α和生存素在结直肠癌进展中的作用。
Int J Colorectal Dis. 2008 Nov;23(11):1057-64. doi: 10.1007/s00384-008-0511-3. Epub 2008 Aug 14.
9
P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.P21 激活激酶 1 通过上调缺氧诱导因子-1α 促进结直肠癌的存活。
Cancer Lett. 2013 Oct 28;340(1):22-9. doi: 10.1016/j.canlet.2013.06.024. Epub 2013 Jun 26.
10
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.在缺氧条件下，SIRT1 的抑制会损害 HIF-1α 蛋白的积累和转录活性。
PLoS One. 2012;7(3):e33433. doi: 10.1371/journal.pone.0033433. Epub 2012 Mar 30.
引用本文的文献
1
Quantitative Phase Imaging Detecting the Hypoxia-Induced Patterns in Healthy and Neoplastic Human Colonic Epithelial Cells.定量相位成像检测健康和肿瘤人类结肠上皮细胞中的缺氧诱导模式。
Cells. 2022 Nov 14;11(22):3599. doi: 10.3390/cells11223599.
2
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.基于生物信息学分析鉴定胰腺癌患者的预后脂质滴相关基因。
Lipids Health Dis. 2021 Jun 2;20(1):58. doi: 10.1186/s12944-021-01476-y.
3
HILPDA Is a Prognostic Biomarker and Correlates With Macrophage Infiltration in Pan-Cancer.HILPDA是一种预后生物标志物，与泛癌中的巨噬细胞浸润相关。
Front Oncol. 2021 Mar 18;11:597860. doi: 10.3389/fonc.2021.597860. eCollection 2021.
4
Lipid droplet storage promotes murine pancreatic tumor growth.脂滴储存促进小鼠胰腺肿瘤生长。
Oncol Rep. 2021 Apr;45(4). doi: 10.3892/or.2021.7972. Epub 2021 Mar 2.
5
Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer.缺氧、缺氧诱导因子 2 (HIG2)/HILPDA 和癌症中的细胞内脂肪分解。
Cancer Lett. 2020 Nov 28;493:71-79. doi: 10.1016/j.canlet.2020.06.013. Epub 2020 Aug 18.
6
Seasonally variant gene expression in full-term human placenta.足月人胎盘季节性变异基因表达。
FASEB J. 2020 Aug;34(8):10431-10442. doi: 10.1096/fj.202000291R. Epub 2020 Jun 23.
7
Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma.成人大脑肿瘤中的肿瘤发展与血管生成：胶质母细胞瘤
Mol Neurobiol. 2020 May;57(5):2461-2478. doi: 10.1007/s12035-020-01892-8. Epub 2020 Mar 9.
8
PVT1 Promotes Cancer Progression via MicroRNAs.PVT1通过微小RNA促进癌症进展。
Front Oncol. 2019 Jul 15;9:609. doi: 10.3389/fonc.2019.00609. eCollection 2019.
9
HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors.HILPDA 调控实体瘤中的脂代谢、脂滴丰度和对外界环境应激的反应。
Mol Cancer Res. 2019 Oct;17(10):2089-2101. doi: 10.1158/1541-7786.MCR-18-1343. Epub 2019 Jul 15.
10
BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer.BLIMP1 诱导胰腺癌中的转移性异质性瞬时变化。
Cancer Discov. 2017 Oct;7(10):1184-1199. doi: 10.1158/2159-8290.CD-17-0250. Epub 2017 Aug 8.
本文引用的文献
1
Targeted genes and interacting proteins of hypoxia inducible factor-1.缺氧诱导因子-1的靶向基因及相互作用蛋白
Int J Biochem Mol Biol. 2012;3(2):165-78. Epub 2012 May 31.
2
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.缺氧诱导因子 1α（HIF1α）和缺氧诱导因子 2α（HIF2α）：在缺氧肿瘤生长和进展中的兄弟之争。
Nat Rev Cancer. 2011 Dec 15;12(1):9-22. doi: 10.1038/nrc3183.
3
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.Cullin3-KLHL20 泛素连接酶依赖性通路靶向 PML 以增强 HIF-1 信号和前列腺癌进展。
Cancer Cell. 2011 Aug 16;20(2):214-28. doi: 10.1016/j.ccr.2011.07.008.
4
Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer.缺氧诱导因子2（HIG2）蛋白在子宫癌中的表达。
Eur J Gynaecol Oncol. 2011;32(2):146-9.
5
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.缺氧诱导蛋白 2 是一种新型的脂滴蛋白，也是缺氧诱导因子-1 的一个特异性靶基因。
FASEB J. 2010 Nov;24(11):4443-58. doi: 10.1096/fj.10-159806. Epub 2010 Jul 12.
6
Feedback regulators of hypoxia-inducible factors and their role in cancer biology.缺氧诱导因子的反馈调节剂及其在癌症生物学中的作用。
Cell Cycle. 2010 Jul 15;9(14):2749-63. doi: 10.4161/cc.9.14.12591. Epub 2010 Jul 30.
7
Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells.人类成丝蛋白 1 是结直肠癌缺氧诱导因子-1α介导迁移的介质。
Cancer Res. 2010 May 15;70(10):4054-63. doi: 10.1158/0008-5472.CAN-09-2110. Epub 2010 May 4.
8
Colon carcinogenesis: Learning from NF-kappaB and AP-1.结直肠癌的发生机制：从 NF-κB 和 AP-1 中学习。
Int J Biochem Cell Biol. 2010 Jul;42(7):1061-5. doi: 10.1016/j.biocel.2010.03.018. Epub 2010 Mar 27.
9
VHL and HIF signalling in renal cell carcinogenesis.VHL 和 HIF 信号通路在肾细胞癌发生中的作用。
J Pathol. 2010 Jun;221(2):125-38. doi: 10.1002/path.2689.
10
Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas.缺氧诱导蛋白 2 在不同组织学类型的上皮性卵巢癌和透明细胞腺癌中的差异表达。
Int J Gynecol Cancer. 2010 Feb;20(2):220-6. doi: 10.1111/IGC.0b013e3181ca1e16.
Zotero 插件